Grants & Awards

Current NIH-funded Grants

2020

 Hepatotoxic effects of perfluoroalkyl substances: a new epidemiological approach for studying environmental fatty liver disease// NIEHS R01 ES030691

The goal of this study is to examine the effects of widely used perfluoroalkyl substances (PFAS) on nonalcoholic fatty liver disease (NAFLD), using the gold standard of liver biopsies for disease diagnosis and liver-specific and plasma metabolomic measures to examine biological mechanisms linking PFAS to liver disease. We will examine this hypothesis in a novel study design using liver and plasma samples from obese adolescents undergoing bariatric surgery. 

Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals// NIEHS R01 ES030364

This study will test the hypothesis that higher levels of persistent chemicals like the DDT metabolite, DDE, that are concentrated in fat, are associated with reduced weight loss and reduced improvement in metabolic health after bariatric surgery. The goal is to develop a new paradigm for studying effects of persistent chemicals in fat that could ultimately lead to new strategies for treatment and prevention.

2019

Environmental Chemical Exposures and Longitudinal Alterations in Glucose Metabolism, Insulin Sensitivity, and B-Cell Function // NIEHS R01 ES029944

The goal of this project is to evaluate the impact of environmental chemical exposures on clinical risk factors for type 2 diabetes in youth and mechanistically relevant pathways using an untargeted metabolomics approach.

Developmental origins of child liver injury: Effects of prenatal environmental exposures // NIEHS R21 ES0293281

This study will assess the associations of early-life exposures to air pollution and environmental chemicals with markers of liver injury in the HELIX project, with the goal to advance the knowledge about environmental contributions to liver disease in humans.

2018

The adipose exposome effects on the plasma metabolome, body composition and metabolic outcomes after bariatric surgery // NIEHS R21 ES028903  

The major goal of this proposal is to propose a novel study to measure lipophilic persistent organic pollutants in visceral adipose tissue collected at bariatric surgery and to examine their effect on the subsequent trajectory of improvement in body composition and clinically relevant metabolic outcomes.

USC Dean’s Pilot Project Award

In 2017, Dr. Chatzi received the USC Keck School of Medicine Dean’s Pilot Project Award for her research entitled “Developmental Origins of Liver Disease”.

Pilot/Feasibility Project Award, Research Center for Liver Diseases

In 2019, Dr. Chatzi was awarded a Pilot/Feasability Award for her proposed project entitled “Perfluorinated compounds and NAFLD improvement after bariatric surgery”